Meenken C, Assies J, van Nieuwenhuizen O, Holwerda-van der Maat W G, van Schooneveld M J, Delleman W J, Kinds G, Rothova A
Department of Ophthalmo-Immunology, The Netherlands Ophthalmic Research Institute, Amsterdam.
Br J Ophthalmol. 1995 Jun;79(6):581-4. doi: 10.1136/bjo.79.6.581.
This study was set up to determine the long term ocular and systemic sequelae in patients with severe congenital toxoplasmosis.
Cross sectional and retrospective study of 17 patients with severe congenital toxoplasmosis.
In addition to chorioretinitis (100%), the most common abnormal ocular features were optic nerve atrophy (83%), visual acuity of less than 0.1 (85%), strabismus, and microphthalmos. In 50% of cases we observed iridic abnormalities and about 40% developed a cataract. Overt endocrinological disease, diagnosed in five of 15 patients, included panhypopituitarism (n = 2), gonadal failure with dwarfism (n = 1), precocious puberty with dwarfism and thyroid deficiency (n = 1), and diabetes mellitus and thyroid deficiency (n = 1). The observed endocrinological involvement was associated in all cases with obstructive hydrocephalus with a dilated third ventricle and optic nerve atrophy.
The recognition of long term ocular, neurological, and endocrinological sequelae of congenital toxoplasmosis is important for medical management of these severely handicapped patients.
本研究旨在确定严重先天性弓形虫病患者的长期眼部和全身后遗症。
对17例严重先天性弓形虫病患者进行横断面和回顾性研究。
除脉络膜视网膜炎（100%）外，最常见的眼部异常特征为视神经萎缩（83%）、视力低于0.1（85%）、斜视和小眼球。在50%的病例中，我们观察到虹膜异常，约40%的患者出现白内障。15例患者中有5例被诊断为明显的内分泌疾病，包括全垂体功能减退（n = 2）、性腺功能减退伴侏儒症（n = 1）、性早熟伴侏儒症和甲状腺功能减退（n = 1）以及糖尿病和甲状腺功能减退（n = 1）。在所有病例中，观察到的内分泌受累均与伴有第三脑室扩张的梗阻性脑积水和视神经萎缩有关。
认识先天性弓形虫病的长期眼部、神经和内分泌后遗症对于这些严重残疾患者的医疗管理很重要。
