van Wersch J W, Peters C, Ubachs H M
Department of Haematology, De Wever Hospital, Heerlen, The Netherlands.
Eur J Clin Chem Clin Biochem. 1995 Apr;33(4):225-9. doi: 10.1515/cclm.1995.33.4.225.
Coagulation and fibrinolysis activation have been investigated in fifty-eight women with recently detected gynaecological tumours. Twenty-six were benign and 32 malignant: of the last group nine patients had metastases. A control group consisted of 31 age-matched healthy women. Prothrombin fragment 1 + 2, thrombin-antithrombin III and D-dimer were measured. The median values of all analytes were significantly higher in the malignant tumour group, but not in the benign tumour group, as compared to the control group. The group of patients with a gynaecological tumour and metastases differed from the non-metastasized tumour group in prothrombin fragment 1 + 2, thrombin-antithrombin III and D-dimer. In the non-metastasized malignant tumour group solely prothrombin fragment 1 + 2 was significantly higher than in the benign tumour group. Coagulation and fibrinolysis predominating as can be derived from the elevated D-dimer/thrombin-antithrombin III and D-dimer/prothrombin fragment 1 + 2 ratios. The studied constituents do not enable a differentiation between the benign and malignant processes. However, as the differences of these values in both malignant tumour groups were significant, this might be used to trace the existence of metastases in gynaecological tumours. Investigation of these analytes in several specific types of gynaecological tumours might be clinically relevant.
对58例近期确诊的妇科肿瘤患者进行了凝血和纤溶激活情况的研究。其中26例为良性肿瘤，32例为恶性肿瘤：在恶性肿瘤组中，9例患者有转移灶。对照组由31名年龄匹配的健康女性组成。检测了凝血酶原片段1+2、凝血酶-抗凝血酶III复合物及D-二聚体。与对照组相比，所有分析物的中位数在恶性肿瘤组显著升高，但在良性肿瘤组中无显著升高。有转移灶的妇科肿瘤患者组与无转移灶的肿瘤组在凝血酶原片段1+2、凝血酶-抗凝血酶III复合物及D-二聚体方面存在差异。在无转移的恶性肿瘤组中，仅凝血酶原片段1+2显著高于良性肿瘤组。从升高的D-二聚体/凝血酶-抗凝血酶III复合物及D-二聚体/凝血酶原片段1+2比值可看出凝血和纤溶占主导。所研究的成分无法区分良性和恶性病变过程。然而，由于这两个恶性肿瘤组中这些值的差异显著，这可能有助于追踪妇科肿瘤转移灶的存在。对几种特定类型妇科肿瘤的这些分析物进行研究可能具有临床意义。
