Nikolaev A Iu, Klepikov P V, Lashutin S V, Kukhtevich A V
Vestn Ross Akad Med Nauk. 1995(5):39-43.
The efficiency of combined therapy (erythropoietin + calcitriol) used in 8 patients with chronic renal failure on programmed hemodialysis was comparatively evaluated with erythropoietin monotherapy employed in 9 patients with the same disease on hemodialysis which represented a control group. The anti-anemia effect was achieved on the average of 5 weeks earlier in the group of patients given the combined therapy than that in the controls. The differences between the two groups were statistically significant in the rate of anti-anemia effect achievement. Possible mechanisms by which calcitriol enhances the anti-anemia effect of erythropoietin, i.e. the mediated effects and direct action of calcitriol on erythropoiesis, are discussed in the paper.
对8例接受计划性血液透析的慢性肾衰竭患者使用联合疗法（促红细胞生成素+骨化三醇）的疗效，与9例接受促红细胞生成素单一疗法的同疾病血液透析患者（作为对照组）进行了比较评估。联合治疗组患者实现抗贫血效果的平均时间比对照组提前约5周。两组在实现抗贫血效果的速率上差异具有统计学意义。本文讨论了骨化三醇增强促红细胞生成素抗贫血作用的可能机制，即骨化三醇对红细胞生成的介导作用和直接作用。
