Lomholt J A, Baggesen K, Ehlers N
Department of Ophthalmology, Arhus University Hospital, Denmark.
Acta Ophthalmol Scand. 1995 Feb;73(1):29-32. doi: 10.1111/j.1600-0420.1995.tb00008.x.
Seventy-two penetrating primary keratoplasties for herpes simplex keratitis performed from 1970 to 1993 were reviewed. Postoperative follow-up periods ranged from 6 months to 16 years with 2 years median. Epithelial herpetic recurrence occurred in 25% of the transplants the first year and in 44% during the first 2 years. Primary allograft rejection was observed in 29% of the grafts the first year and in 46% during the first 2 years. Preoperative inflammation was a risk factor for preservation of a clear cornea (p < 0.10). The degree of corneal vascularization prior to operation did not influence the survival of the grafts. The overall one-year survival rate of a clear graft was 84% and the 2-year survival rate was 67%. Prophylactic antiviral treatment is discussed.
回顾了1970年至1993年期间为单纯疱疹性角膜炎施行的72例穿透性原发性角膜移植术。术后随访时间为6个月至16年，中位数为2年。移植后的第一年，25%的患者出现上皮性疱疹复发，前两年复发率为44%。第一年29%的移植物发生原发性同种异体移植排斥反应，前两年为46%。术前炎症是角膜保持透明的一个危险因素（p<0.10）。术前角膜血管化程度不影响移植物的存活。透明移植物的总体一年存活率为84%，两年存活率为67%。文中还讨论了预防性抗病毒治疗。
