Eagon J C, Kelly K A
Department of Surgery, Mayo Clinic, Rochester, MN 55905, USA.
Neurogastroenterol Motil. 1995 Mar;7(1):39-45. doi: 10.1111/j.1365-2982.1995.tb00207.x.
The aim was to measure the effect of gastric electrical stimulation on the frequency of canine antral pacesetter potentials (PPs), the strength of antral contractions, and the rate of gastric emptying while fasting, after feeding and with pentagastrin stimulation. Four conscious dogs with a stimulating electrode placed 10 cm proximal to the pylorus and recording electrodes and strain gauges placed 7, 5 and 3 cm proximal to the pylorus underwent myoelectric and strain gauge recordings while fasting, after feeding (250 ml 5% dextrose labelled with polyethylene glycol), and during pentagastrin infusion (0.5 micrograms kg-1 min-1) on four separate days. On each day, electrical stimulation was done using one of four stimulation frequencies (0, 6, 30 and 1200 stimuli per minute [s.p.m.]). Stimulation at 6 and 30 s.p.m. increased the fasting and fed PP frequency, whereas 1200 s.p.m. stimulation did not. Feeding decreased the maximum driven frequency, and pentagastrin increased it. Neither the motility index nor the gastric emptying rate were consistently changed by stimulation at any frequency. In conclusion, canine proximal antral stimulation at 6 and 30 s.p.m. sped PP frequency during fasting and after feeding, but stimulation over a wide range of frequencies had little effect on gastric contractions and emptying.
目的是测量胃电刺激对犬空腹、进食后以及五肽胃泌素刺激时胃窦起步电位（PPs）频率、胃窦收缩强度和胃排空速率的影响。四只清醒犬，在幽门近端10 cm处放置刺激电极，在幽门近端7、5和3 cm处放置记录电极和应变仪，分别在空腹、进食后（250 ml用聚乙二醇标记的5%葡萄糖）以及五肽胃泌素输注期间（0.5微克·千克⁻¹·分钟⁻¹）进行肌电和应变仪记录，记录在四天内完成。每天使用四种刺激频率之一（每分钟0、6、30和1200次刺激[s.p.m.]）进行电刺激。6和30 s.p.m.的刺激增加了空腹和进食后的PP频率，而1200 s.p.m.的刺激则没有。进食降低了最大驱动频率，五肽胃泌素则增加了该频率。任何频率的刺激均未持续改变运动指数和胃排空速率。总之，6和30 s.p.m.的犬近端胃窦刺激在空腹和进食后加快了PP频率，但广泛频率范围内的刺激对胃收缩和排空影响不大。
