Kubonishi I, Sugito S, Kobayashi M, Asahi Y, Tsuchiya T, Yamashiro T, Miyoshi I
Department of Medicine, Kochi Medical School, Japan.
Cancer Genet Cytogenet. 1995 Jul 1;82(1):54-6. doi: 10.1016/0165-4608(94)00290-r.
A 54-year old man with a primary lung lymphoma of mucosa-associated lymphoid tissue (MALT) origin whose tumor cells had a t(11;12;18)(q13;q13;q12) chromosome abnormality is described. The morphologic, immunologic, and molecular biologic investigations showed that the patient's lung tumor consisted of small lymphoid cells that expressed monoclonal IgM, kappa-type immunoglobulin, and immunoglobulin gene (JH and C kappa) rearrangements. Cytogenetic study revealed that the tumor cells contained a unique chromosome translocation, t(11;12;18)(q13;q13;q12), that has not been reported previously in lymphoma.
本文描述了一名54岁男性，其原发性肺黏膜相关淋巴组织（MALT）淋巴瘤起源的肿瘤细胞存在t(11;12;18)(q13;q13;q12)染色体异常。形态学、免疫学和分子生物学研究表明，患者的肺肿瘤由表达单克隆IgM、κ型免疫球蛋白以及免疫球蛋白基因（JH和Cκ）重排的小淋巴细胞组成。细胞遗传学研究显示，肿瘤细胞含有一种独特的染色体易位t(11;12;18)(q13;q13;q12)，此前在淋巴瘤中尚未见报道。
