van Echten J, van den Berg E, van Baarlen J, van Noort G, Vermey A, Dam A, Molenaar W M
Department of Medical Genetics, University Hospital of Groningen, The Netherlands.
Cancer Genet Cytogenet. 1995 Jul 1;82(1):57-61. doi: 10.1016/0165-4608(94)00291-i.
A cytogenetic study of two cases of alveolar soft part sarcoma showed near-diploid karyotypes with multiple chromosomal rearrangements. An abnormality of the long arm of chromosome 17, involving band q25, is present in both cases and in 2 of 4 cases in the literature. This recurrent structural abnormality probably plays an important role in the histogenesis of this unusual neoplasm and therefore is important for further molecular investigation.
两例肺泡软组织肉瘤的细胞遗传学研究显示，核型接近二倍体，伴有多个染色体重排。两例病例以及文献报道的4例中的2例，均存在17号染色体长臂涉及q25带的异常。这种反复出现的结构异常可能在这种罕见肿瘤的组织发生中起重要作用，因此对进一步的分子研究很重要。
