Nakamura M, Oda M, Inoue J, Ito T, Akiba Y, Kitajima M, Tsuchiya M, Ishii H
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
Dig Dis Sci. 1995 Jul;40(7):1451-8. doi: 10.1007/BF02285191.
Basic fibroblast growth factor (bFGF) has well-established angiogenic and ulcer healing actions. bFGF has also been found to induce neural regeneration in the central nervous system. Thus, the present study was undertaken to clarify the effect of basic fibroblast growth factor on the regeneration of autonomic nerves in the granulation tissues following the induction of experimental gastric ulcer induced by acetic acid in rats. Rats were divided into control, acetic acid alone, and acetic acid plus acid-stable human recombinant basic fibroblast growth factor (CS23, 1 microgram/100 g body wt., every 12 hr for three days, or one or two weeks, through oral gastric intubation) groups. As a result, few autonomic nerves were recognized surrounding the newly formed arterioles and venules in the acetic acid alone group. In the CS23-treated group, the cholinergic, calcitonin gene-related peptide and vasoactive intestinal peptide-immunoreactive nerves were clearly recognized near the microvessels, but few adrenergic nerves were seen even after CS23 treatment. From these observations, basic fibroblast growth factor was suggested to promote the reinnervation of the newly formed microvessels.
碱性成纤维细胞生长因子（bFGF）具有公认的血管生成和溃疡愈合作用。人们还发现bFGF可诱导中枢神经系统的神经再生。因此，本研究旨在阐明碱性成纤维细胞生长因子对大鼠乙酸诱导实验性胃溃疡后肉芽组织中自主神经再生的影响。将大鼠分为对照组、单纯乙酸组和乙酸加酸稳定型人重组碱性成纤维细胞生长因子组（CS23，1微克/100克体重，每12小时一次，持续三天，或通过经口胃插管给药一或两周）。结果，在单纯乙酸组中，新形成的小动脉和小静脉周围几乎没有发现自主神经。在CS23治疗组中，在微血管附近可清楚地识别出胆碱能、降钙素基因相关肽和血管活性肠肽免疫反应性神经，但即使经过CS23治疗，也很少见到肾上腺素能神经。从这些观察结果来看，碱性成纤维细胞生长因子被认为可促进新形成微血管的神经再支配。
