Lombertie E R, Salome N, Villegier P, Laghrissi-Thode F, Nassif F
Praticien hospitalier, SHU de Psychiatrie, Secteur IV, CH Esquirol, Limoges.
Encephale. 1995 Jun;21 Spec No 3:29-33.
The authors, taking up their experience and the literature, attempt to view the precociousness of alternative, classical neuroleptic treatments in schizophrenia, from notion of treatment-resistant schizophrenia, precocious refractory and intolerance. Until now, clozapine was administrated to patients lasting resistant and in mainly cases hospitalized since many years. As such as quality of life and economy of health, it would be desirable to quickly think of alternatives neuroleptic's therapeutic protocols and clozapine in the treatment-resistant schizophrenias or those presenting an intolerance.
作者结合自身经验及文献，试图从难治性精神分裂症、早期难治性及不耐受的概念出发，审视在精神分裂症中替代经典抗精神病药物治疗的早熟性。到目前为止，氯氮平一直用于长期耐药的患者，且主要是多年来住院的患者。就生活质量和健康经济而言，最好能尽快考虑在难治性精神分裂症或那些出现不耐受情况的患者中使用替代抗精神病药物治疗方案及氯氮平。
