Gürsel I, Hasirci V
Middle East Technical University, Department of Biological Sciences, Ankara, Turkey.
J Microencapsul. 1995 Mar-Apr;12(2):185-93. doi: 10.3109/02652049509015289.
Microcapsules of poly(3-hydroxybutyric acid) [PHB] and its copolymers with hydroxyvalerate [HV] were prepared by the solvent evaporation technique and loaded with a model drug, 2,7-dichlorofluorescein. Microcapsules were also prepared from the same polymers by incorporating a polyphosphate-Ca+2 complex into the membrane. The morphology of the microcapsules varied by the change in the type of polymer used, by the introduction of drug and by the incorporation of the complex. Drug release behaviour, encapsulation efficiency and loading were all found to be influenced by the polymer type. The DSC results revealed that upon incorporation of valerate as the co-monomer, the crystallinity of the polymer decreased, leading to a material with more segmental mobility. This probably was the reason why the loading and encapsulation efficiency of the homopolymer were lower than those of the copolymers. DSC also indicated that the complex became an integral part of the membrane.
通过溶剂蒸发技术制备了聚（3-羟基丁酸）[PHB]及其与羟基戊酸[HV]的共聚物的微胶囊，并负载了模型药物2,7-二氯荧光素。还通过将多磷酸盐-Ca+2络合物掺入膜中，由相同的聚合物制备了微胶囊。微胶囊的形态因所用聚合物类型的变化、药物的引入以及络合物的掺入而有所不同。发现药物释放行为、包封效率和载药量均受聚合物类型的影响。DSC结果表明，引入戊酸作为共聚单体后，聚合物的结晶度降低，导致材料具有更高的链段流动性。这可能就是均聚物的载药量和包封效率低于共聚物的原因。DSC还表明，该络合物成为膜的一个组成部分。
