Takazawa H
Department of Pathology, Chiba National Hospital.
Nihon Rinsho. 1995 Jul;53(7):1672-7.
The expression of the VLA-integrins beta 1, -2, -3, -5, -6 and alpha v beta 3 was studied immunohistochemically in the tissue sample from human colon-cancer. Furthermore, histological stage-grouping of the colon-cancer (I-V), additional vascular invasion such as lymphatic and blood-vessel invasion, was made to express the malignancy of the carcinoma, for making a comparison with the expression of the integrins. Immunohistologically, beta 1, VLA-2, and alpha v beta 3 were mildly expressed in the carcinoma cells and VLA-6, markedly expressed. These findings were not correlated with the malignant stage-grouping. For VLA-3, the carcinoma showed mild to marked expression with a diffuse distribution on the cell surface in the peripheral area of the carcinoma, nearly correlating with the histological stage of malignancy. While, the expression of VLA-5 was almost absent in the carcinoma. These results suggest that the enhanced expression of VLA-3 with suppressed expression of VLA-5 is functionally important for the carcinoma cell invasion and also for the metastasis.
采用免疫组织化学方法研究了VLA整合素β1、β2、β3、β5、β6和αvβ3在人结肠癌组织样本中的表达。此外，对结肠癌进行组织学分期分组（I - V期），并观察有无淋巴管和血管等额外的血管侵犯情况，以此来表示癌症的恶性程度，以便与整合素的表达情况进行比较。免疫组织化学结果显示，β1、VLA - 2和αvβ3在癌细胞中呈轻度表达，VLA - 6呈显著表达。这些结果与恶性分期分组无关。对于VLA - 3，癌组织表现为轻度至显著表达，在癌组织周边区域细胞表面呈弥漫性分布，几乎与恶性组织学分期相关。而VLA - 5在癌组织中几乎不表达。这些结果表明，VLA - 3表达增强而VLA - 5表达受抑制对癌细胞侵袭和转移在功能上具有重要意义。
