Iwata H, Kobayashi S, Iwase H, Okada Y
Second Department of Surgery, Nagoya City University Medical School.
Nihon Rinsho. 1995 Jul;53(7):1805-10.
Tumor cells degrade extracellular matrix components (ECM) to invade surrounding tissues. Malignant tumor cells are known to produce various ECM-degrading enzymes including matrix metalloproteinases (MMPs), serine proteinases and cathepsins. Among them, MMPs may play a key role in cancer invasion and metastasis. To study the role of MMPs in the progression of human breast carcinomas, we examined production and tissue localization of MMP-1, MMP-2, MMP-3, MMP-9 and their common inhibitors, tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2). The data suggest that the imbalance between MMPs and TIMPs produced by tumor tissues may be a determinant of the progression in breast carcinoma.
肿瘤细胞通过降解细胞外基质成分（ECM）来侵袭周围组织。已知恶性肿瘤细胞会产生多种ECM降解酶，包括基质金属蛋白酶（MMPs）、丝氨酸蛋白酶和组织蛋白酶。其中，MMPs可能在癌症侵袭和转移中起关键作用。为了研究MMPs在人类乳腺癌进展中的作用，我们检测了MMP-1、MMP-2、MMP-3、MMP-9及其常见抑制剂金属蛋白酶组织抑制剂（TIMP-1和TIMP-2）的产生和组织定位。数据表明，肿瘤组织产生的MMPs和TIMPs之间的失衡可能是乳腺癌进展的一个决定因素。
