Jendiroba D, Younes A, Katz R, Hill D, Cabanillas F, Andreeff M
Department of Hematology, University of Texas MD Anderson Cancer Center, Houston 77030, USA.
Leukemia. 1995 Jul;9(7):1144-6.
Monosomy 17 and structural abnormalities of the short arm of chromosome 17 have been reported to influence prognosis and treatment outcome in patients with non-Hodgkin's lymphoma (NHL). In diffuse large cell lymphoma, these abnormalities were associated with refractoriness to chemotherapy, higher proliferative rate and poor prognosis. We studied the incidence of chromosome 17 abnormalities in 55 patients with NHL by using fluorescence in situ hybridization with a directly conjugated centromeric probe for chromosome 17. Twenty-three patients (42%) were previously untreated. Thirty-four patients (62%) had diffuse large cell lymphoma, 18 (33%) had follicular low-grade lymphoma, one had small lymphocytic lymphoma, one had diffuse mixed cell lymphoma, and one had mantle cell lymphoma. Cells from benign lymphoid hyperplasia were used as controls. Eight patients (15%) had trisomy 17 in 1.2-40.7% of cells and one patient (1.8%) had monosomy 17 in 68.8% of cells. We conclude that monosomy 17 is not common in NHL. Chromosome 17 deletions should be investigated with region-specific probes to determine their clinical relevance in NHL.
据报道，17号染色体单体及17号染色体短臂结构异常会影响非霍奇金淋巴瘤（NHL）患者的预后和治疗结果。在弥漫性大细胞淋巴瘤中，这些异常与化疗耐药、较高的增殖率及不良预后相关。我们采用与17号染色体直接偶联的着丝粒探针进行荧光原位杂交，研究了55例NHL患者中17号染色体异常的发生率。23例患者（42%）此前未接受过治疗。34例患者（62%）患有弥漫性大细胞淋巴瘤，18例（33%）患有滤泡性低级别淋巴瘤，1例患有小淋巴细胞淋巴瘤，1例患有弥漫性混合细胞淋巴瘤，1例患有套细胞淋巴瘤。来自良性淋巴样增生的细胞用作对照。8例患者（15%）的细胞中17号染色体三体率为1.2% - 40.7%，1例患者（1.8%）的细胞中17号染色体单体率为68.8%。我们得出结论，17号染色体单体在NHL中并不常见。应使用区域特异性探针研究17号染色体缺失情况，以确定其在NHL中的临床相关性。
