Higuchi I, Hashimoto K, Kashio N, Izumo S, Inose M, Izumi K, Ohkubo R, Nakagawa M, Arimura K, Osame M
Third Department of Internal Medicine, Kagoshima University, Japan.
Muscle Nerve. 1995 Aug;18(8):854-8. doi: 10.1002/mus.880180809.
We tested for HTLV-I proviral DNA in skeletal muscle from patients with polymyositis infected with HTLV-I using the in situ polymerase chain reaction. We found the HTLV-I provirus in some of the CD4-positive cells in HTLV-I-positive polymyositis cases but not in HTLV-I-negative polymyositis ones. We could not detect HTLV-I within the muscle fibers. We suggest that HTLV-I-associated polymyositis is not due to direct, persistent infection of the muscle fiber by the virus, but to a T-cell-mediated immunological process triggered by the HTLV-I-infected cells.
我们使用原位聚合酶链反应检测了感染人嗜T淋巴细胞病毒I型（HTLV-I）的多发性肌炎患者骨骼肌中的HTLV-I前病毒DNA。我们在HTLV-I阳性的多发性肌炎病例的一些CD4阳性细胞中发现了HTLV-I前病毒，但在HTLV-I阴性的多发性肌炎病例中未发现。我们在肌纤维内未检测到HTLV-I。我们认为，HTLV-I相关性多发性肌炎并非由该病毒直接持续感染肌纤维所致，而是由HTLV-I感染细胞触发的T细胞介导的免疫过程所致。
