患有多肌炎的病毒携带者肌肉中主要携带人类嗜T淋巴细胞病毒I型（HTLV-I）的细胞不是巨噬细胞，而是CD4 +淋巴细胞。
The main HTLV-I-harboring cells in the muscles of viral carriers with polymyositis are not macrophages but CD4+ lymphocytes.
作者信息
Higuchi I, Hashimoto K, Matsuoka E, Rosales R, Nakagawa M, Arimura K, Izumo S, Osame M
机构信息
Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan.
出版信息
Acta Neuropathol. 1996 Oct;92(4):358-61. doi: 10.1007/s004010050530.
We have analyzed muscle biopsy specimens from polymyositis patients who are also positive for human T cell lymphotropic virus type I (HTLV-I) using both immunohistochemistry for surface antigens of lymphocytes and macrophages and in situ polymerase chain reaction for HTLV-I proviral DNA on the same sections. We found HTLV-I in CD4+ cells but not in macrophages. This finding suggests that most of the HTLV-I-containing CD4+ cells are not macrophages but lymphocytes.
我们使用淋巴细胞和巨噬细胞表面抗原的免疫组织化学方法以及同一切片上HTLV-I前病毒DNA的原位聚合酶链反应，分析了同时感染I型人类嗜T细胞病毒（HTLV-I）的多发性肌炎患者的肌肉活检标本。我们在CD4+细胞中发现了HTLV-I，但在巨噬细胞中未发现。这一发现表明，大多数含有HTLV-I的CD4+细胞不是巨噬细胞，而是淋巴细胞。
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