Viral Immunology Section, Neuroimmunology Branch, NIH, Building 10, Room 5C-103, Bethesda, MD 20892, USA.
J Neuroimmune Pharmacol. 2010 Sep;5(3):310-25. doi: 10.1007/s11481-010-9216-9. Epub 2010 May 2.
Human T-lymphotrophic virus type I (HTLV-I) is an oncogenic retrovirus and its infection is associated with a variety of human diseases including HTLV-I-associated myelopathy/tropic spastic paraparesis (HAM/TSP). Large numbers of epidemiological, virological, immunological, and clinical studies on HTLV-I- and HTLV-I-associated diseases have been published, although the pathogenesis of HAM/TSP remains to be fully understood. In the last several years, researchers have shown that several key factors are important in HTLV-I-associated neurologic disease including high HTLV-I proviral load and a strong immune response to HTLV-I. Here, we review pathophysiological findings on HAM/TSP and focus on viral-host immune responses to the virus in HTLV-I infected individuals. In particular, the role of HTLV-I-specific CD8+ T cell response is highlighted.
人类 T 淋巴细胞病毒 I 型（HTLV-I）是一种致癌逆转录病毒，其感染与多种人类疾病相关，包括 HTLV-I 相关性脊髓病/热带痉挛性截瘫（HAM/TSP）。尽管 HAM/TSP 的发病机制尚未完全阐明，但已经发表了大量关于 HTLV-I 和 HTLV-I 相关疾病的流行病学、病毒学、免疫学和临床研究。在过去的几年中，研究人员表明，几个关键因素在 HTLV-I 相关神经疾病中很重要，包括高 HTLV-I 前病毒载量和对 HTLV-I 的强烈免疫反应。在这里，我们回顾了 HAM/TSP 的病理生理学发现，并重点关注 HTLV-I 感染个体中病毒-宿主免疫反应。特别是，强调了 HTLV-I 特异性 CD8+ T 细胞反应的作用。
