Marinaccio M, Traversa A, Carioggia E, Valentino L, Coviello M, Salamanna S, Dragone D C, Marinaccio L
I Clinica Ginecologica e Ostetrica, Università degli Studi di Bari.
Minerva Ginecol. 1995 Mar;47(3):69-76.
A retrospective analysis of 968 women affected by gynecological tumors was conducted to assess the existence of a difference in survival between patients with different blood groups. Data are presented on 237 cases of endometrial cancer, 92 cases of ovarian cancer and 639 cases of invasive cervix cancer, detailing their ABO blood antigenic phenotypes, the stage of neoplasia and the treatment received. With regard to endometrial cancer, a sensibly better 5-year and 10-year survival is associated with blood group 0 if compared with blood group A. This finding is more evident when 5-year survival is considered among patients affected by ovarian cancer. With regard to cervical cancer, analysis showed that a little better than 5-year survival is associated with 0 blood phenotype; on the contrary, when a 10-year or longer survival is considered, a better survival is associated with A blood phenotype. The present study confirms evidence of an association between the A blood group and gynecological tumors. Endometrial and ovarian cancer occur more frequently in women with blood type A than in those with the other blood types, moreover, in the same tumors blood group A is associated with a poor prognosis. The possible reason for these findings are discussed with detailed regard to the possible biological importance that, at present, is conferred to the ABO group system in the complex activities of the immune system.
对968名患有妇科肿瘤的女性进行了回顾性分析，以评估不同血型患者的生存差异。呈现了237例子宫内膜癌、92例卵巢癌和639例浸润性宫颈癌的数据，详细说明了它们的ABO血型抗原表型、肿瘤分期和接受的治疗。对于子宫内膜癌，与A型血相比，0型血的5年和10年生存率明显更高。在考虑卵巢癌患者的5年生存率时，这一发现更为明显。对于宫颈癌，分析表明0型血表型的5年生存率略高；相反，当考虑10年或更长时间的生存率时，A型血表型的生存率更高。本研究证实了A型血与妇科肿瘤之间存在关联的证据。子宫内膜癌和卵巢癌在A型血女性中比在其他血型女性中更常见，此外，在相同肿瘤中，A型血与预后不良有关。针对目前ABO血型系统在免疫系统复杂活动中可能具有的生物学重要性，详细讨论了这些发现的可能原因。
