Mandato Vincenzo Dario, Torricelli Federica, Mastrofilippo Valentina, Vacca Ilaria, Melli Beatrice, Generali Matteo, Annunziata Gianluca, Pirillo Debora, D'Ippolito Giovanni, Ciarlini Gino, Aguzzoli Lorenzo
Unit of Obstetrics and Gynecologic Oncology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Laboratory of Translational Research, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.
J Cancer. 2024 Jul 9;15(15):4777-4788. doi: 10.7150/jca.95245. eCollection 2024.
Cervical cancer is the most common genital cancer worldwide and is mainly caused by a persistent human papillomavirus infection. Well-known prognostic factors are age, histology, stage, stromal invasion, tumor size, and tumor grade. The relationship between the ABO and Rh system with cervical cancer has been studied since the 1950s, though without obtaining clear results. Here we investigated the association between the ABO blood group and Rh system and consecutively treated cervical cancer patients in our department. Clinical charts of cervical cancer patients treated and followed from 2010 to 2021 were checked for inclusion and exclusion criteria. Clinical and pathological data were recorded in a separate, anonymous, password-protected electronic database. All relevant data were extrapolated and used for final analysis. A population of 143 cervical cancer patients was analyzed in this study. 47.6% (68/143) were blood group O, 36.4% (52/143) were blood group A, 8.4% (12/143) were blood group AB, and 7.7% (11/143) were blood group B. 14.9% (21/141) were RhD negative, while 85.1% (120/141) were RhD positive. No significant association was found between the ABO group and survival. However, patients with blood types B and AB had a higher BMI than the other blood types. RhD-negative patients exhibited a lower age at diagnosis (P=0.035) and had a higher overall survival compared to RhD-positive patients. The RhD factor appears to influence cervical cancer OS, but the data are too weakly significant to draw a definitive conclusion. Further studies with larger samples are needed to confirm this finding and to investigate the true impact of blood groups in female cancers.
宫颈癌是全球最常见的妇科癌症，主要由持续性人乳头瘤病毒感染引起。众所周知的预后因素包括年龄、组织学类型、分期、间质浸润、肿瘤大小和肿瘤分级。自20世纪50年代以来，人们一直在研究ABO血型系统和Rh血型系统与宫颈癌之间的关系，但尚未得出明确结果。在此，我们调查了ABO血型系统和Rh血型系统与我院连续收治的宫颈癌患者之间的关联。检查了2010年至2021年接受治疗和随访的宫颈癌患者的临床病历，以确定纳入和排除标准。临床和病理数据记录在一个单独的、匿名的、有密码保护的电子数据库中。所有相关数据均被提取并用于最终分析。本研究分析了143例宫颈癌患者。47.6%（68/143）为O型血，36.4%（52/143）为A型血，8.4%（12/143）为AB型血，7.7%（11/143）为B型血。14.9%（21/141）为RhD阴性，而85.1%（120/141）为RhD阳性。未发现ABO血型与生存率之间存在显著关联。然而，B型和AB型血的患者体重指数高于其他血型。RhD阴性患者诊断时年龄较低（P=0.035），与RhD阳性患者相比总生存率较高。RhD因子似乎影响宫颈癌的总生存期，但数据的显著性太弱，无法得出明确结论。需要进一步进行更大样本量的研究来证实这一发现，并调查血型在女性癌症中的真正影响。
