Weick R F, Stobie K M
Department of Physiology, University of Western Ontario, London, Canada.
Neurosci Biobehav Rev. 1995 Summer;19(2):251-9. doi: 10.1016/0149-7634(94)00057-8.
Vasoactive intestinal peptide (VIP) is found within neurons throughout the body. It influences the secretion of several hormones of the anterior pituitary by neural and pituitary actions. We review work from our laboratory that indicates that VIP inhibits the secretion of luteinizing hormone (LH) by a hypothalamic action. Experiments involving neural lesions indicate that VIP acts on the receptor field in the paraventricular nuclei of neurons whose cell bodies are located in the suprachiasmatic nuclei. The effect on LH secretion is subsequently mediated by a nonVIPergic pathway, which does not appear to involve either dopamine or endogenous opioids. Experiments with the specific VIP antagonist, [4Cl-D-Phe6,Leu17]VIP, indicate that the actions on LH secretion of VIP and of the related peptides, growth hormone-releasing hormone and secretin, are mediated by VIP-preferring receptors. VIP also blocks the steroid-induced LH surge in the ovariectomized rat. The VIP antagonist induces a significant, but small increase in LH secretion in the intact rat, indicating that VIP has a modulatory, rather than deterministic, role in the regulation of LH secretion.
血管活性肠肽（VIP）存在于全身的神经元内。它通过神经和垂体作用影响垂体前叶多种激素的分泌。我们回顾了我们实验室的研究工作，这些研究表明VIP通过下丘脑作用抑制促黄体生成素（LH）的分泌。涉及神经损伤的实验表明，VIP作用于细胞体位于视交叉上核的神经元室旁核中的受体区域。对LH分泌的影响随后由一条非VIP能途径介导，该途径似乎不涉及多巴胺或内源性阿片类物质。使用特异性VIP拮抗剂[4Cl-D-Phe6,Leu17]VIP的实验表明，VIP以及相关肽促生长激素释放激素和促胰液素对LH分泌的作用是由优先结合VIP的受体介导的。VIP还能阻断去卵巢大鼠中类固醇诱导的LH峰。VIP拮抗剂在完整大鼠中可诱导LH分泌显著但小幅增加，这表明VIP在LH分泌调节中起调节作用而非决定性作用。
