Recent research using brain imaging and molecular biological methods has clarified our knowledge about the cause of schizophrenia. The picture emerging is of a group of illnesses with their origins in neurodevelopmental abnormalities. The most severe forms of schizophrenia are accompanied by defects in memory and attention. There are several implications of this new knowledge for nursing. Our current nursing models are less than adequate and represent outdated and discredited theory. Additionally we must consider new ways of working with people who have what are essentially brain diseases. However, it is also clear that social and psychological factors are crucial in determining outcome and quality of life for people with schizophrenia and their families. The Thorn Programme, which trains nurses in case management and various psychosocial interventions, exemplifies the way forward for mental health nursing and such developments will secure a place for the profession in the services of the future.