Kugelmass S, Faber N, Ingraham L J, Frenkel E, Nathan M, Mirsky A F, Ben Shakhar G
Department of Psychology, Hebrew University, Jerusalem, Israel.
Schizophr Bull. 1995;21(2):205-17. doi: 10.1093/schbul/21.2.205.
In an earlier study, skin conductance orienting response (SCOR) and anxiety measures obtained when the subjects of the Israeli High-Risk Study were 11 years old were analyzed, using adult diagnostic information, when the subjects were 26 years old. The present study considers similar data obtained from most of this sample when the subjects were 16 years old. As in the earlier analysis, those subjects who would receive a schizophrenia spectrum diagnosis at 26 had higher anxiety ratings at age 16. Nondiagnosed index subjects also had significantly higher anxiety ratings than the nondiagnosed controls. The subjects who would receive affective spectrum diagnoses at age 26 had the most hyporesponsive SCORs, as predicted, while the subjects who would later be diagnosed in the schizophrenia spectrum had an unexpected hyperresponsive SCOR to the dishabituation tone in a habituation series. Further consideration of the long-term stability of SCORs seems necessary; they may be related to the developing psychopathological processes.
在一项早期研究中，利用以色列高危研究对象26岁时的成人诊断信息，分析了这些对象11岁时的皮肤电导率定向反应（SCOR）和焦虑测量值。本研究考虑了该样本中大部分对象16岁时获得的类似数据。与早期分析一样，那些在26岁时会被诊断为精神分裂症谱系障碍的对象在16岁时焦虑评分更高。未被诊断的指标对象的焦虑评分也显著高于未被诊断的对照组。正如所预测的那样，那些在26岁时会被诊断为情感谱系障碍的对象的SCOR反应最低，而那些后来会被诊断为精神分裂症谱系障碍的对象在习惯化系列中对去习惯化音调的SCOR反应出乎意料地高。似乎有必要进一步考虑SCOR的长期稳定性；它们可能与心理病理过程的发展有关。
