Kendler K S, Walsh D
Dept. of Psychiatry, Richmond, VA 23298-0710, USA.
Schizophr Bull. 1995;21(1):47-52. doi: 10.1093/schbul/21.1.47.
With on exception, previous studies examining the familial relationship between schizotypal personality disorder (SPD) and schizophrenia have compared rates of SPD in relatives of probands with schizophrenia versus control probands. In the Roscommon Family Study, an epidemiologically based family study of major psychiatric disorders conducted in the west of Ireland, we used a Cox proportional hazards model to examine the impact of a parental diagnosis of SPD on the risk for psychiatric disorders in siblings of probands with schizophrenia or schizophrenia spectrum disorders. In siblings of probands with schizophrenia or schizophrenia spectrum, a parental diagnosis of SPD significantly increased the risk for schizophrenia and schizophrenia spectrum disorders, but not for affective illness or anxiety disorders. These findings replicate our previous results from the Roscommon Family Study, further supporting the hypothesis that SPD has a substantial familial relationship with schizophrenia and other schizophrenia spectrum disorders, but not with affective illness.
除一项研究外，以往探讨分裂型人格障碍（SPD）与精神分裂症之间家族关系的研究，均比较了精神分裂症先证者亲属与对照先证者中SPD的发生率。在罗斯康芒家族研究中，这是一项在爱尔兰西部开展的基于流行病学的主要精神障碍家族研究，我们使用Cox比例风险模型，来检验父母一方被诊断为SPD对患有精神分裂症或精神分裂症谱系障碍先证者兄弟姐妹患精神障碍风险的影响。在患有精神分裂症或精神分裂症谱系障碍先证者的兄弟姐妹中，父母一方被诊断为SPD会显著增加其患精神分裂症和精神分裂症谱系障碍的风险，但不会增加患情感性疾病或焦虑症的风险。这些发现重复了我们之前在罗斯康芒家族研究中的结果，进一步支持了以下假设：SPD与精神分裂症及其他精神分裂症谱系障碍存在实质性家族关系，但与情感性疾病无关。
