Suzuki S, Kelley R E, Reyes-Iglesias Y, Alfonso V M, Dietrich W D
Department of Neurology, University of Miami School of Medicine, Fla., USA.
South Med J. 1995 Aug;88(8):819-24. doi: 10.1097/00007611-199508000-00005.
We prospectively evaluated the inflammatory response to acute cerebral ischemia in 57 patients who were seen within 72 hours of ictus. All subjects had cerebrospinal fluid examination, complete blood count, sedimentation rate determination, and body temperature monitoring. Correlation analysis was done between these measurements and infarct volume, which was determined by computed tomography of the brain. We found a positive linear correlation between infarct size and the peripheral white blood cell count, specifically the polymorphonuclear leukocyte count. A relationship was also observed for the cerebrospinal fluid protein level, the gamma globulin level, and the cerebrospinal fluid/serum albumin ratio. The correlations observed presumably reflect the extent of tissue injury and secondary inflammatory response in acute cerebral ischemia.
我们前瞻性地评估了57例在发病72小时内就诊的急性脑缺血患者的炎症反应。所有受试者均进行了脑脊液检查、全血细胞计数、血沉测定和体温监测。对这些测量值与通过脑部计算机断层扫描确定的梗死体积进行了相关性分析。我们发现梗死面积与外周白细胞计数，特别是多形核白细胞计数之间存在正线性相关。还观察到脑脊液蛋白水平、γ球蛋白水平和脑脊液/血清白蛋白比值之间存在关联。观察到的相关性可能反映了急性脑缺血中组织损伤的程度和继发性炎症反应。
