Büttner T, Hornig C R, Busse O, Dorndorf W
J Neurol. 1986 Oct;233(5):297-303. doi: 10.1007/BF00314162.
The severity of neurological deficits, size of hypodense zone on CT, concentration of cAMP and activity of adenylate kinase in cerebrospinal fluid (CSF) were evaluated at predefined intervals in the acute stage of supratentorial cerebral ischaemic infarction in 52 patients. Patients with cerebral infarction had raised activities of adenylate kinase CSF as compared with normal persons. Patients with marked neurological deficits, only slight improvement of neurological signs and large infarction zones on CT had higher average activities of adenylate kinase and lower concentration of cAMP in CSF. Alterations of CSF adenylate kinase and CSF cAMP values were most distinct on the 3rd day after the stroke. Reasons for the changes may be metabolic disorders following brain ischaemia.
在52例幕上脑缺血性梗死急性期，按照预定时间间隔对神经功能缺损的严重程度、CT上低密度区的大小、脑脊液（CSF）中cAMP的浓度以及腺苷酸激酶的活性进行了评估。与正常人相比，脑梗死患者脑脊液中腺苷酸激酶的活性升高。神经功能缺损明显、神经体征仅略有改善且CT上梗死灶较大的患者，脑脊液中腺苷酸激酶的平均活性较高，cAMP浓度较低。脑脊液腺苷酸激酶和脑脊液cAMP值的变化在卒中后第3天最为明显。这些变化的原因可能是脑缺血后的代谢紊乱。
