Vachvanichsanong P, Patamasucon P, Malagon M, Moore E S
Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat-Yai, Thailand.
Pediatr Nephrol. 1995 Jun;9(3):346-7. doi: 10.1007/BF02254206.
A 9-year-old boy developed acute renal failure following intravenous acyclovir (30 mg/kg per day) administered for 6 days to treat herpetic encephalitis. Physical findings and urine output were normal, except for increasing blood urea nitrogen (BUN), serum creatinine and mild proteinuria. Acyclovir was discontinued. However BUN and serum creatinine continued to increase and peaked on the following day at 8.6 mmol/l of urea (24 mg/dl) and 194 mumol/l (2.2 mg/ml), respectively. Conservative treatment and hydration were carried out. The kidney function returned to normal within 1 week. The use of acyclovir when necessary in renal failure patients is discussed.
一名9岁男孩在静脉注射阿昔洛韦（每天30 mg/kg）6天以治疗疱疹性脑炎后出现急性肾衰竭。除血尿素氮（BUN）、血清肌酐升高及轻度蛋白尿外，体格检查及尿量均正常。停用阿昔洛韦。然而，BUN和血清肌酐继续升高，次日分别达到峰值，尿素为8.6 mmol/l（24 mg/dl），肌酐为194 μmol/l（2.2 mg/ml）。进行了保守治疗及补液。肾功能在1周内恢复正常。文中讨论了肾衰竭患者必要时使用阿昔洛韦的情况。
