Kintz P, Cirimele V, Edel Y, Tracqui A, Mangin P
Institut de Médecine Légale, Strasbourg, France.
Int J Legal Med. 1995;107(5):269-72. doi: 10.1007/BF01245487.
By providing information on exposure to drugs over time, hair analysis is useful in verifying the history of drug use. In a clinical case, where drug abuse was denied, it was possible to identify dextromoramide in the hair of the subject. After acid hydrolysis of the hair with 0.1 M HCl, in the presence of SKF 525A as an internal standard, the drug was extracted at pH 8.4 with chloroform-isopropanol-n-heptane (50:17:33 v/v) and quantified by gas chromatography/mass spectrometry. The hair strands were cut into 3 sections of 2.5 cm, corresponding to a growth period of 2 months. Concentrations were 1.09, 1.93 and 1.48 ng/mg from the root to the end, respectively. This is the first report on dextromoramide testing in human hair.
通过提供一段时间内的药物暴露信息，毛发分析有助于核实吸毒史。在一个否认药物滥用的临床案例中，能够在受试者的毛发中检测到右吗拉胺。用0.1 M盐酸对毛发进行酸水解后，在作为内标的SKF 525A存在的情况下，于pH 8.4用氯仿-异丙醇-正庚烷（50:17:33 v/v）萃取药物，并通过气相色谱/质谱法进行定量。将毛发剪成三段，每段2.5厘米，分别对应两个月的生长周期。从发根到发梢的浓度分别为1.09、1.93和1.48 ng/mg。这是关于人毛发中右吗拉胺检测的首篇报道。
