Lazaris A C, Theodoropoulos G E, Aroni K, Saetta A, Davaris P S
Department of Pathology, Medical School of Athens University, Greece.
Virchows Arch. 1995;426(5):461-7. doi: 10.1007/BF00193169.
The clinical course of malignant melanomas is frequently unpredictable, although a number of prognostically useful variables can be identified. There is a need for additional markers of prognostic value. In a series of 60 malignant cutaneous melanomas, we analysed the immunohistochemical expression of c-myc proto-oncogene, heat shock protein 70 (HSP70) and HLA-DR molecules in order to investigate their prognostic significance. C-myc, HSP70 and HLA-DR were expressed in 43.3%, 56.6% and 38.3% of all melanoma cases, respectively. Advanced Clark levels (Clark III-V) were significantly associated with c-myc expression rate (P < 0.05), HSP70 detection (P < 0.01) and HLA-DR positivity (P < 0.01). Increased Breslow thickness (> 1.5 mm) was related to HLA-DR expression (P < 0.05). High mitotic rate was closely associated with c-myc positivity (P < 0.05), while HSP70 and HLA-DR expression separately correlated to clinical stage of the disease (P < 0.05). The evaluation of these variables may be of immunological and prognostic significance. They were found to be associated with melanocyte subpopulations of the vertical growth phase which are arguably characterized by an increased invasive potential.
恶性黑色素瘤的临床病程常常难以预测，尽管可以确定一些具有预后参考价值的变量。仍需要其他具有预后价值的标志物。在一系列60例皮肤恶性黑色素瘤中，我们分析了c-myc原癌基因、热休克蛋白70（HSP70）和HLA-DR分子的免疫组化表达，以研究它们的预后意义。c-myc、HSP70和HLA-DR在所有黑色素瘤病例中的表达率分别为43.3%、56.6%和38.3%。较高的克拉克分级（克拉克三级至五级）与c-myc表达率（P < 0.05）、HSP70检测结果（P < 0.01）和HLA-DR阳性率（P < 0.01）显著相关。 Breslow厚度增加（> 1.5 mm）与HLA-DR表达有关（P < 0.05）。高有丝分裂率与c-myc阳性密切相关（P < 0.05），而HSP70和HLA-DR表达分别与疾病的临床分期相关（P < 0.05）。对这些变量的评估可能具有免疫学和预后意义。它们被发现与垂直生长期的黑素细胞亚群有关，这些亚群可以说是以侵袭潜能增加为特征。
