Fullen D R, Headington J T
Department of Pathology, University of Michigan Hospitals, Ann Arbor, USA.
J Cutan Pathol. 1998 Nov;25(10):553-8. doi: 10.1111/j.1600-0560.1998.tb01740.x.
Fifty nevomelanocytic lesions, including 10 typical compound nevi and 20 radial and 20 vertical growth-phase melanomas, were evaluated for factor XIIIa and HLA-DR (LN3) expression within dermal dendritic cells (DDCs) or dermal dendrocytes to determine if DDCs proliferate and/or participate as possible antigen-presenting cells in the local tissue response to benign and malignant nevomelanocytic lesions. There was no statistical difference in factor XIIIa staining of DDCs between nevi and radial or vertical growth-phase melanomas, suggesting that DDCs do not significantly proliferate in nevomelanocytic lesions. However, studies to determine proliferation rate, apoptosis, and influences of local mediators on cell growth and/or recruitment were not done. HLA-DR staining by DDCs was significantly increased (p<0.001) in both melanoma groups when compared to compound nevi, but did not significantly differ between radial and vertical growth-phase melanomas. The intensity of HLA-DR expression appeared to correlate with the presence or absence of lymphocytic inflammation; HLA-DR intensity was judged greater in melanomas characterized by a brisk and infiltrative lymphocytic host response. We propose that DDCs may participate in the dermal immune response to invasive melanomas, probably as antigen-presenting cells to skin-associated lymphocytes.
对50个痣黑素细胞性病变进行了评估，其中包括10个典型的复合痣、20个放射状生长阶段和20个垂直生长阶段的黑色素瘤，检测真皮树突状细胞（DDCs）或真皮树突状细胞中因子ⅩⅢa和HLA-DR（LN3）的表达，以确定DDCs是否增殖和/或作为可能的抗原呈递细胞参与局部组织对良性和恶性痣黑素细胞性病变的反应。痣与放射状或垂直生长阶段黑色素瘤的DDCs中因子ⅩⅢa染色无统计学差异，提示DDCs在痣黑素细胞性病变中无明显增殖。然而，尚未进行确定增殖率、凋亡以及局部介质对细胞生长和/或募集影响的研究。与复合痣相比，两个黑色素瘤组中DDCs的HLA-DR染色均显著增加（p<0.001），但放射状和垂直生长阶段黑色素瘤之间无显著差异。HLA-DR表达强度似乎与淋巴细胞炎症的有无相关；在以活跃且浸润性淋巴细胞宿主反应为特征的黑色素瘤中，HLA-DR强度被判定更高。我们认为DDCs可能参与对侵袭性黑色素瘤的真皮免疫反应，可能作为皮肤相关淋巴细胞的抗原呈递细胞。
