Laversuch C J, Brown M M, Clifton A, Bourke B E
Department of Rheumatology, St George's Hospital, London.
Br J Rheumatol. 1995 Jun;34(6):572-5. doi: 10.1093/rheumatology/34.6.572.
A 42-yr-old woman with hypertension and renal involvement due to systemic lupus erythematosus (SLE) developed unilateral headache followed by the sudden onset of confusion and a grand mal convulsion. Cerebral computed tomography was normal. A magnetic resonance imaging angiogram revealed cerebral venous thrombosis and a venous infarct. Nephrotic syndrome had resulted in an acquired protein S deficiency. A review of previous cases suggests that either renal disease with proteinuria or features of the antiphospholipid syndrome are prerequisites for the development of cerebral venous thrombosis in SLE. Low free-protein S levels may be an additional risk factor. Furthermore it is likely that this condition is underdiagnosed.
一名42岁患有高血压且因系统性红斑狼疮（SLE）累及肾脏的女性，出现单侧头痛，随后突然出现意识模糊和癫痫大发作。脑部计算机断层扫描结果正常。磁共振成像血管造影显示脑静脉血栓形成和静脉梗死。肾病综合征导致获得性蛋白S缺乏。对既往病例的回顾表明，SLE患者发生脑静脉血栓形成的先决条件是蛋白尿性肾病或抗磷脂综合征的特征。低游离蛋白S水平可能是一个额外的危险因素。此外，这种情况很可能未得到充分诊断。
