Dolan A L, Kassimos D, Gibson T, Kingsley G H
Department of Rheumatology, Guy's Hospital, London.
Br J Rheumatol. 1995 Jun;34(6):576-8. doi: 10.1093/rheumatology/34.6.576.
There is no widely accepted treatment for the calcinosis which occurs in scleroderma and dermatomyositis. We report a case of a 62-yr-old woman with active scleroderma complicated by tuberose calcinosis. The calcinosis, which had previously been unchanged for several years, regressed over a 2-yr period during which diltiazem was used to treat hypertension. This effect could not be explained by altered disease activity or renal function but, we suggest, may be due to inhibition of calcium influx into cells. This treatment merits further evaluation.
对于硬皮病和皮肌炎中出现的钙质沉着症，目前尚无广泛认可的治疗方法。我们报告一例62岁患有活动性硬皮病并伴有结节性钙质沉着症的女性病例。此前数年一直未变的钙质沉着症，在使用地尔硫䓬治疗高血压的两年期间逐渐消退。这种效果无法用疾病活动度或肾功能的改变来解释，但我们认为，可能是由于抑制了钙流入细胞所致。这种治疗方法值得进一步评估。
