Lirng J F, Tien R D, Osumi A K, Madden J F, McLendon R P, Sexton D
Department of Radiology, National Yang-Ming University, Taipei, Taiwan, R.O.C.
Zhonghua Yi Xue Za Zhi (Taipei). 1995 Jun;55(6):491-5.
Cerebral phaeohyphomycosis is used to describe the rare clinical syndrome of cerebral infection caused by dematiaceous (i.e. pigmented olivaceous-brown) fungi. It usually presents as brain abscess. In view of the rarity of this fungal infection and its clinical importance, we report a case of cerebral phaeohyphomycosis caused by Xylohypha bantiana. The patient presented with a seizure attack. The MRI study revealed a ring-enhancing lesion with marked perifocal edema in right high frontoparietal junction of the brain. He underwent an initial craniotomy for removal of the lesion and a second craniotomy for recurrence of the lesion 3 months later. The diagnosis was based on successful cultivation of X. bantiana from the surgical specimen and on histopathology. The patient received antifungal drug therapy of 5-flucytosine and itraconazole. He has done well without any symptoms. We think complete surgical removal of the brain abscess combined with antifungal drug therapy is the best management for this rare fungal disease.
脑暗色丝孢霉病用于描述由暗色（即色素沉着呈橄榄棕色）真菌引起的脑部感染这一罕见临床综合征。它通常表现为脑脓肿。鉴于这种真菌感染的罕见性及其临床重要性，我们报告一例由班替木丝霉引起的脑暗色丝孢霉病病例。患者出现癫痫发作。磁共振成像（MRI）研究显示在脑右侧额顶叶高部位交界处有一个环形强化病灶，周围有明显水肿。他最初接受了开颅手术以切除病灶，3个月后因病灶复发又进行了一次开颅手术。诊断基于从手术标本中成功培养出班替木丝霉以及组织病理学检查。患者接受了5-氟胞嘧啶和伊曲康唑的抗真菌药物治疗。他恢复良好，没有任何症状。我们认为完全切除脑脓肿并结合抗真菌药物治疗是这种罕见真菌疾病的最佳治疗方法。
