Sekhon A S, Galbraith J, Mielke B W, Garg A K, Sheehan G
National Reference Centre for Human Mycotic Diseases, University of Alberta, Edmonton, Canada.
Eur J Epidemiol. 1992 May;8(3):387-90. doi: 10.1007/BF00158573.
A 76-year-old male with chief complaints of back and right leg sciatica was hospitalized. His abdominal CT scan revealed lumber spondylitic stenosis. A laminectomy was performed. Postoperatively, he became febrile, aphasic and had grand mal seizure. A left craniotomy of the front abscess, seen in the CT scan, was performed. H and E stained smears of drainage revealed dematiaceous, septate hyphae. Cultures of the abscess drainage grew an olivaceous-grey fungus. Based on macro- and micro-morphological characters, growth at 42 degrees C, and exoantigenic analysis, the patient's fungus was identified as Xylohypha bantiana. Treatment with amphotericin B and 5-fluorocytosine was initiated. Despite surgical procedures and antifungal therapy, the patient's condition deteriorated and he died a few weeks later due to cerebral edema. The case reported here is the first microscopically, culturally, histopathologically and exoantigenically proven case of phaeohyphomycosis caused by X. bantiana in the province of Alberta and from Canada. A review of the literature on cases of X. bantiana infections has also been presented.
一名76岁男性因背部疼痛和右腿坐骨神经痛为主诉入院。腹部CT扫描显示腰椎管狭窄。行椎板切除术。术后，他出现发热、失语并发生癫痫大发作。对CT扫描中所见的左侧额叶脓肿进行了开颅手术。引流液的苏木精-伊红染色涂片显示有暗色、分隔菌丝。脓肿引流液培养长出一种橄榄灰色真菌。根据宏观和微观形态特征、42℃生长情况及外抗原分析，患者的真菌被鉴定为班替木霉。开始用两性霉素B和5-氟胞嘧啶治疗。尽管进行了手术和抗真菌治疗，患者病情仍恶化，几周后因脑水肿死亡。本文报告的病例是艾伯塔省及加拿大首例经显微镜、培养、组织病理学和外抗原证实由班替木霉引起的暗色丝孢霉病病例。还对有关班替木霉感染病例的文献进行了综述。
