George T P, Sernyak M J, Ziedonis D M, Woods S W
Department of Psychiatry, Yale University School of Medicine, CT, USA.
J Clin Psychiatry. 1995 Aug;56(8):344-6.
The effects of clozapine administration on smoking were examined in chronic schizophrenic outpatients.
Twenty-nine of 30 schizophrenic outpatients enrolled in a university-affiliated Community Mental Health Center clozapine clinic were retrospectively surveyed by semistructured questionnaire regarding smoking before and after clozapine administration.
Smokers comprised 62% (N = 18) of patients, and within this group, there was a significant decrease in reported daily cigarette use during clozapine treatment compared with level of use when patients had been treated with typical neuroleptics (1.67 +/- 1.13 vs. 1.26 +/- 0.72 packs/day, p = .025).
Clozapine may alter smoking behaviors in chronic schizophrenics.
在慢性精神分裂症门诊患者中研究了氯氮平给药对吸烟的影响。
通过半结构化问卷对一所大学附属社区心理健康中心氯氮平诊所登记的30例精神分裂症门诊患者中的29例进行回顾性调查，了解其在服用氯氮平前后的吸烟情况。
吸烟者占患者的62%（N = 18），在该组中，与使用典型抗精神病药物治疗时相比，氯氮平治疗期间报告的每日吸烟量显著减少（1.67±1.13包/天对1.26±0.72包/天，p = 0.025）。
氯氮平可能会改变慢性精神分裂症患者的吸烟行为。
