Hamann I D, Hepburn N C, Hunter J A
Department of Dermatology, University of Edinburgh, Royal Infirmary, Edinburgh, Scotland, UK.
J R Soc Med. 1995 May;88(5):296P-297P.
Chronic bullous dermatosis of childhood (CBDC) is a distinctive subepidermal blistering disorder that characteristically involves the perioral area, lower trunk, inner thighs and genitalia. Direct immunofluorescence shows a linear band of IgA at the dermoepidermal junction (DEJ). The eruption usually begins before the age of 6 years and is typically described as self-limiting, clearing with a few months or years. Chronic bullous dermatosis of childhood has many clinical and immunopathological similarities with adult linear IgA disease (LAD) and it has been suggested that they represent different manifestations of the same disease. We report a case of CBDC which started at 2 years of age and which has relapsed twice, first at age 6 years and then again, after puberty, at age 17 years.
儿童慢性大疱性皮肤病（CBDC）是一种独特的表皮下大疱性疾病，其特征性地累及口周区域、下腹部、大腿内侧和生殖器。直接免疫荧光显示在真皮表皮交界处（DEJ）有一条IgA线性带。皮疹通常在6岁之前开始，通常被描述为自限性，在数月或数年内消退。儿童慢性大疱性皮肤病与成人线状IgA疾病（LAD）有许多临床和免疫病理学相似之处，有人认为它们是同一疾病的不同表现形式。我们报告一例CBDC病例，该病例始于2岁，曾复发两次，第一次在6岁时，第二次在青春期后的17岁时。
