Isosu T, Katoh M, Okuaki A
Department of Anesthesiology, Iwate Prefectural Iwai Hospital, Ichinoseki.
Masui. 1995 Jul;44(7):1014-7.
We investigated the proper dosage of droperidol continuously infused into the epidural space. Sixty patients who received continuous epidural infusion of buprenorphine for 24 hours were divided into four groups (Group I: only buprenorphine, Group II: 1.25 mg of droperidol added to buprenorphine, Group III: 2.5 mg of droperidol added to buprenorphine, Group IV: 5 mg of droperidol added to buprenorphine). No significant difference was observed in prevention of nausea and vomiting among 4 groups. But in group II, III and IV, there was a tendency of increased analgesic effects of buprenorphine. Especially in group III, the pain level was significantly lower and number of doses of bupivacaine was significantly fewer than in group I. In conclusion, droperidol 2.5 mg continuously infused into epidural space increases analgesic effects of buprenorphine.
我们研究了持续注入硬膜外腔的氟哌利多的合适剂量。60例接受丁丙诺啡持续硬膜外输注24小时的患者被分为四组(第一组:仅用丁丙诺啡;第二组:在丁丙诺啡中加入1.25毫克氟哌利多;第三组:在丁丙诺啡中加入2.5毫克氟哌利多;第四组:在丁丙诺啡中加入5毫克氟哌利多)。四组在预防恶心和呕吐方面未观察到显著差异。但在第二组、第三组和第四组中,丁丙诺啡的镇痛效果有增加的趋势。特别是在第三组中,疼痛程度明显低于第一组,布比卡因的用药剂量也明显少于第一组。总之,持续注入硬膜外腔2.5毫克氟哌利多可增强丁丙诺啡的镇痛效果。