Watanabe K, Terashima M, Isosu T, Komatsu T, Ohtsuki M, Okuaki A
Department of Anesthesiology, Central Aizu General Hospital, Aizuwakamatsu.
Masui. 1995 Jul;44(7):950-5.
We reported that PuO2 reflects renal medullary perfusion and decreases during N2O-O2 isoflurane (GOI) or sevoflurane (GOS) anesthesia. In the present study, we examined the effect of dopamine (DOA) or prostaglandin E1 (PGE1) on PuO2 during GOI anesthesia. Twenty four patients from elective surgery with GOI anesthesia were randomly divided into three groups, i.e. control group (n = 8), DOA group (n = 8) and PGE1 group (n = 8). PuO2 decreased significantly in the control group, while in the DOA and PGE1 groups, PuO2 was unchanged. These results suggest that DOA and PGE1 maintain renal medullary perfusion under GOI anesthesia.
我们曾报道过，肾髓质氧分压（PuO2）可反映肾髓质灌注情况，且在氧化亚氮 - 氧气 - 异氟烷（GOI）或七氟烷（GOS）麻醉期间会降低。在本研究中，我们检测了多巴胺（DOA）或前列腺素E1（PGE1）对GOI麻醉期间PuO2的影响。24例行GOI麻醉择期手术的患者被随机分为三组，即对照组（n = 8）、DOA组（n = 8）和PGE1组（n = 8）。对照组中PuO2显著降低，而DOA组和PGE1组中PuO2未发生变化。这些结果表明，DOA和PGE1在GOI麻醉下可维持肾髓质灌注。
