Hayakawa J, Itoh T, Kanemura K, Shibata T, Usuda Y
Department of Anesthesia, Kanagawa Cancer Center Hospital, Yokohama.
Masui. 1994 May;43(5):684-8.
We evaluated the effects of dopamine (DA) and PGE1 on portal venous oxygenation in patients undergoing gastrectomy. Thirty-two patients studied were anesthetized with isoflurane and nitrous oxide in oxygen. They were divided into three groups: DA was infused at a rate of 3 micrograms.kg-1.min-1 in 10 patients (DA group), PGE1 was infused at a rate of 0.02 microgram.kg-1.min-1 in 10 patients (PGE1 group), and the remainders did not receive DA nor PGE1 (control group). There were no significant differences in PaO2 and SaO2 among three groups. However, portal venous PO2 and SaO2 in DA and PGE1 group were significantly higher than those in the control group. These results suggest that DA and PGE1 elevate the portal venous PO2 and SO2 by increasing splanchnic blood flow more than its oxygen uptake or without increasing splanchnic oxygen uptake, and increase the oxygen supply to the liver.
我们评估了多巴胺（DA）和前列腺素E1（PGE1）对接受胃切除术患者门静脉氧合的影响。研究的32例患者采用异氟烷和氧化亚氮混合氧气进行麻醉。他们被分为三组：10例患者以3微克·千克-1·分钟-1的速率输注多巴胺（多巴胺组），10例患者以0.02微克·千克-1·分钟-1的速率输注前列腺素E1（前列腺素E1组），其余患者未接受多巴胺和前列腺素E1（对照组）。三组之间的动脉血氧分压（PaO2）和动脉血氧饱和度（SaO2）无显著差异。然而，多巴胺组和前列腺素E1组的门静脉血氧分压（PO2）和血氧饱和度（SaO2）显著高于对照组。这些结果表明，多巴胺和前列腺素E1通过增加内脏血流量超过其氧摄取量或不增加内脏氧摄取量来提高门静脉PO2和SO2，并增加肝脏的氧供应。
