Taneyama C, Fujita T, Kohno N
Department of Anesthesiology, Suwa Red Cross Hospital.
Masui. 1993 Oct;42(10):1429-34.
The purpose of this study is to investigate and compare the reflex heart rate response to bolus injections of prostaglandin E1 (PGE1) and to nitroglycerin (NTG). One hundred and fifty seven patients under isoflurane nitrous oxide in oxygen anesthesia were studied prior to elective surgery. They were divided into following two groups: NTG group; n = 101 (male 54, female 47), 49.8 +/- 19.1 years of age, and PGE1 group; n = 56 (male 31, female 25), 54.7 +/- 15.3 years of age. The bolus injections of NTG and PGE1 produced a significant increase in heart rate as an indicator of arterial baroreflex response. However, there was no statistical difference between the two groups. Negative linear relationship between age and magnitude of reflex heart rate response to reduction of blood pressure (delta HR/delta SBP) was present in NTG group (r = -0.57, P < 0.01) and PGE1 group (r = -0.50, P < 0.01). These results suggest that the degree of the reflex heart rate response to bolus injection of NTG and PGE1 is almost identical in patients under isoflurane anesthesia.
本研究的目的是调查和比较静脉注射前列腺素E1（PGE1）和硝酸甘油（NTG）后反射性心率反应。对157例在异氟烷、氧化亚氮和氧气麻醉下接受择期手术的患者进行了研究。他们被分为以下两组：NTG组，n = 101（男54例，女47例），年龄49.8±19.1岁；PGE1组，n = 56（男31例，女25例），年龄54.7±15.3岁。静脉注射NTG和PGE1后，作为动脉压力反射反应指标的心率显著增加。然而，两组之间没有统计学差异。NTG组（r = -0.57，P < 0.01）和PGE1组（r = -0.50，P < 0.01）中，年龄与血压降低时反射性心率反应幅度（δHR/δSBP）之间存在负线性关系。这些结果表明，在异氟烷麻醉的患者中，静脉注射NTG和PGE1后反射性心率反应的程度几乎相同。
