Gormus B J, Xu K, Baskin G B, Martin L N, Bohm R P, Blanchard J L, Mack P A, Ratterree M S, McClure H M, Meyers W M
Department of Microbiology, Tulane Regional Primate Research Center, Covington, LA, USA.
Lepr Rev. 1995 Jun;66(2):96-104. doi: 10.5935/0305-7518.19950012.
A total of 31 sooty mangabey monkeys (SMM) (Cercocebus torquatus atys) inoculated by various routes with differing numbers of SMM-origin Mycobacterium leprae (ML) and 4 SMM inoculated with human-origin ML were observed for 4-12 years. SMM-origin ML was more pathogenic in SMM than human-origin ML. The spectrum of disease ranged from indeterminate to borderline and lepromatous in different animals. Some animals developed pure neural leprosy. Erythema nodosum leprosum (SNL) was also observed. Combined intravenous/intracutaneous (IV/IC) routes of inoculation more effectively induced advancing, disseminated lepromatous forms of leprosy; IV or IC routes alone were less effective at comparable doses. Total IV/IC doses of SMM-origin ML equal to or greater than 5 x 10(8), with morphologic indices (MIs) ranging from 5 to 10%, produced advancing, disseminated LL leprosy in 92% of SMM. Lower IV/IC doses and inoculations by a single IV or IC route produced fewer leprosy infections and more spontaneous regressions. As a species, captive SMM are highly susceptible to experimental leprosy and provide an excellent model for the longitudinal study of leprosy.
对31只通过不同途径接种不同数量的来自黑猩猩的麻风分枝杆菌（ML）的黑猩猩（SMM）（Cercocebus torquatus atys）以及4只接种来自人类的ML的SMM进行了4至12年的观察。来自SMM的ML对SMM的致病性比来自人类的ML更强。疾病谱在不同动物中从未定类到界线类和瘤型不等。一些动物发展为纯神经型麻风。还观察到了结节性红斑麻风（SNL）。静脉内/皮内联合（IV/IC）接种途径更有效地诱导了进行性、播散性瘤型麻风；单独的IV或IC途径在相当剂量下效果较差。来自SMM的ML的IV/IC总剂量等于或大于5×10⁸，形态学指数（MIs）范围为5%至10%，在92%的SMM中产生了进行性、播散性瘤型麻风。较低的IV/IC剂量以及通过单一IV或IC途径接种产生的麻风感染较少且自发消退较多。作为一个物种，圈养的SMM对实验性麻风高度敏感，为麻风的纵向研究提供了一个极好的模型。
