Carroll S B
Howard Hughes Medical Institute, University of Wisconsin at Madison 53706, USA.
Nature. 1995 Aug 10;376(6540):479-85. doi: 10.1038/376479a0.
Clusters of homeotic genes sculpt the morphology of animal body plans and body parts. Different body patterns may evolve through changes in homeotic gene number, regulation or function. Recent evidence suggests that homeotic gene clusters were duplicated early in vertebrate evolution, but the generation of arthropod and tetrapod diversity has largely involved regulatory changes in the expression of conserved arrays of homeotic genes and the evolution of interactions between homeotic proteins and the genes they regulate.
同源异型基因簇塑造了动物身体结构和身体部位的形态。不同的身体模式可能通过同源异型基因数量、调控或功能的变化而进化。最近的证据表明，同源异型基因簇在脊椎动物进化早期就发生了复制，但节肢动物和四足动物多样性的产生很大程度上涉及同源异型基因保守阵列表达的调控变化以及同源异型蛋白与其调控基因之间相互作用的进化。
