Kunze W A, Bornstein J C, Furness J B
Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, Australia.
Neuroscience. 1995 May;66(1):1-4. doi: 10.1016/0306-4522(95)00067-s.
It is commonly believed that the cell bodies of mammalian sensory neurons are contained within spinal and cranial sensory ganglia associated with the central nervous system or within the central nervous system itself. However, strong circumstantial evidence implies that some sensory neurons are contained entirely within the gastrointestinal tract. We have investigated this possibility by using intracellular methods to record the responses of myenteric neurons in the guinea-pig small intestine to physiological stimuli applied to the neighbouring mucosa. The results show that the myenteric plexus contains a population of chemosensitive sensory neurons and that these neurons correspond to neurons with AH electrophysiological properties and Dogiel type II morphology. This is the first direct evidence that some sensory neurons are contained entirely within the peripheral nervous system.
人们普遍认为，哺乳动物感觉神经元的细胞体包含在与中枢神经系统相关的脊髓和颅感觉神经节内，或者在中枢神经系统本身内。然而，有力的间接证据表明，一些感觉神经元完全包含在胃肠道内。我们通过使用细胞内方法记录豚鼠小肠肌间神经丛神经元对施加于邻近黏膜的生理刺激的反应，来研究这种可能性。结果表明，肌间神经丛包含一群化学敏感的感觉神经元，并且这些神经元与具有AH电生理特性和多极II型形态的神经元相对应。这是一些感觉神经元完全包含在周围神经系统内的首个直接证据。
