Shimizu K, Hibino H, Komenami N, Nagai N, Nagai K, Nakagawa H
Division of Protein Metabolism, Osaka University, Japan.
Neurosci Lett. 1994 Jul 4;175(1-2):157-60. doi: 10.1016/0304-3940(94)91103-7.
We previously obtained evidence that in rats the neurons in the suprachiasmatic nucleus (SCN) receiving retinal neural inputs may be involved in the regulation of glucose metabolism. In this study we examined whether the SCN neurons containing vasoactive intestinal peptide (VIP)-like immunoreactive substance (VIP neurons) are involved in its regulation. We found that the hyperglycemic and hyperglucagonemic responses to intracranial injection of 2-deoxy-D-glucose (2DG) were synergistically enhanced by intracranial administration of VIP, and that these responses were significantly suppressed by treatment with anti-VIP antibody. These results suggest that VIP has a permissive effect on the hyperglycemic and hyperglucagonemic responses to 2DG, and thus that the VIP neurons in the SCN are probably involved in the regulation of glucose metabolism.
我们之前获得的证据表明，在大鼠中，接受视网膜神经输入的视交叉上核（SCN）中的神经元可能参与葡萄糖代谢的调节。在本研究中，我们检测了含有血管活性肠肽（VIP）样免疫反应物质的SCN神经元（VIP神经元）是否参与其调节。我们发现，颅内注射VIP可协同增强对颅内注射2-脱氧-D-葡萄糖（2DG）的高血糖和高胰高血糖素反应，并且这些反应可通过抗VIP抗体治疗而显著受到抑制。这些结果表明，VIP对2DG的高血糖和高胰高血糖素反应具有允许作用，因此SCN中的VIP神经元可能参与葡萄糖代谢的调节。
