褪黑素可抑制大鼠脑室内注射2-脱氧-D-葡萄糖所致的高血糖。

Melatonin suppresses hyperglycemia caused by intracerebroventricular injection of 2-deoxy-D-glucose in rats.

作者信息

Shima T, Chun S J, Niijima A, Bizot-Espiard J G, Guardiola-Lemaitre B, Hosokawa M, Nagai K

机构信息

Division of Protein Metabolism, Institute for Protein Research, Osaka University, Suita, Japan.

出版信息

Neurosci Lett. 1997 Apr 25;226(2):119-22. doi: 10.1016/s0304-3940(97)00257-7.

DOI:10.1016/s0304-3940(97)00257-7

PMID:9159504

Abstract

To elucidate the role of melatonin (MT), we examined the effects of intracranial injection of MT and an MT-antagonist (S20928) on the hyperglycemic response to intracranial injection of 2-deoxy-D-glucose (2DG) in rats. The hyperglycemic and hyperglucagonemic responses caused by intracerebroventricular injection of 2DG were inhibited by intracerebroventricular co-injection of MT, but enhanced by co-injection of the MT-antagonist. Intraperitoneal injection of MT also inhibited the hyperglycemic response, though the inhibition seemed to be less than that after intracranial injection of MT. These results suggest that MT plays an endogenously suppressive role in the hyperglycemia caused by 2DG, possibly through a brain site.

摘要

为了阐明褪黑素（MT）的作用，我们研究了颅内注射MT和MT拮抗剂（S20928）对大鼠颅内注射2-脱氧-D-葡萄糖（2DG）后高血糖反应的影响。脑室内注射2DG引起的高血糖和高胰高血糖素反应可被脑室内联合注射MT抑制，但被MT拮抗剂联合注射增强。腹腔注射MT也抑制了高血糖反应，尽管这种抑制作用似乎小于颅内注射MT后的抑制作用。这些结果表明，MT可能通过脑内位点对2DG引起的高血糖发挥内源性抑制作用。