Ebert U, Löscher W
Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany.
Neurosci Lett. 1995 May 12;190(3):199-202. doi: 10.1016/0304-3940(95)11540-d.
The effect of conventional and rapid amygdala kindling on mossy fibre sprouting and on the development of secondary after-discharges in the hippocampus, i.e. recurring after-discharges after the end of primary after-discharges in the amygdala, was investigated. Rapid kindling, i.e. electric stimulation of the amygdala for 10 s every 30 min, induced prolonged secondary after-discharges in the hippocampus, which occurred after the first stimulation, and mossy fibre sprouting. Conventional kindling, i.e. electric stimulation of the amygdala for 1 s once daily, induced secondary after-discharges in the hippocampus only after prolonged motor seizures, but no mossy fibre sprouting. These results suggest that mossy fibre sprouting and the occurrence of secondary after-discharges in the hippocampus are not crucial for conventional amygdala kindling. Rapid kindling induces these epileptogenic changes in the hippocampus very early and may therefore follow a different route of epileptogenesis than conventional kindling.
研究了传统杏仁核点燃和快速杏仁核点燃对苔藓纤维出芽以及海马中继发性放电后发放（即在杏仁核原发性放电结束后反复出现的后发放）发展的影响。快速点燃，即每30分钟对杏仁核进行10秒的电刺激，可诱发海马中持续时间较长的继发性后发放，其在首次刺激后出现，并伴有苔藓纤维出芽。传统点燃，即每天对杏仁核进行1次1秒的电刺激，仅在长时间运动性癫痫发作后才诱发海马中的继发性后发放，但未出现苔藓纤维出芽。这些结果表明，苔藓纤维出芽和海马中继发性后发放的出现对于传统杏仁核点燃并非至关重要。快速点燃可在很早的时候就在海马中诱发这些致痫性变化，因此其癫痫发生途径可能与传统点燃不同。
