Tatarkiewicz J
Zakład Farmakodynamiki Akademii Medycznej w Warszawie.
Postepy Hig Med Dosw. 1994;48(5):505-20.
Structure, biological activity, mode and mechanism of action of botulinum toxin as well as its therapeutic use is described. Botulinum toxin type A, one of the most potent biologic toxins, has been found to be of therapeutic value in the treatment of several neurologic and ophthalmologic diseases. Its ability to produce chemical denervation of muscles makes it option for treatment of disorders in which traditional therapeutic procedures are of limited value (e.g. blepharospasm and other focal dystonias, strabismus, spasticity).
本文描述了肉毒杆菌毒素的结构、生物活性、作用方式和作用机制及其治疗用途。A型肉毒杆菌毒素是最有效的生物毒素之一，已发现在治疗多种神经和眼科疾病方面具有治疗价值。它能够使肌肉产生化学去神经作用，这使其成为治疗传统治疗方法价值有限的疾病（如眼睑痉挛和其他局灶性肌张力障碍、斜视、痉挛）的选择。
