Giladi N, Meer J, Kidan C, Greenberg E, Gross B, Honigman S
Department of Neurology, Carmel Medical Center, Haifa, Israel.
Isr J Med Sci. 1994 Nov;30(11):816-9.
Local injections of botulinum toxin is a well-accepted treatment for focal dystonias, hemifacial spasms and strabismus. Its use by skilled neurologists has been reported to be safe and effective. We report our experience with botulinum toxin injections in 108 patients with various central nervous system disorders. Botox was effective in upper face dystonia (86% improvement), spastic dysphonia (92% improvement), platysma muscle spasms and spasmodic torticollis (range of movement 61%, pain and tension 90%). It was also very effective in a few patients with apraxia of eyelid opening, parkinsonian jaw tremor, teeth clenching, palatal myoclonus and adductor leg spasticity. No serious side effects were recorded. Botulinum toxin is a useful symptomatic treatment for many neurological disorders, and one of the leading mode of treatments in the new subspecialty in neurology called "Interventional neurology."
局部注射肉毒杆菌毒素是治疗局灶性肌张力障碍、半面痉挛和斜视的一种广泛接受的方法。据报道，熟练的神经科医生使用该方法是安全有效的。我们报告了对108例患有各种中枢神经系统疾病的患者进行肉毒杆菌毒素注射的经验。肉毒杆菌毒素对上面部肌张力障碍（改善率86%）、痉挛性发音困难（改善率92%）、颈阔肌痉挛和痉挛性斜颈（活动范围改善61%，疼痛和紧张感改善90%）有效。对少数眼睑开合失用症、帕金森病性下颌震颤、牙关紧闭、腭肌阵挛和内收肌腿部痉挛患者也非常有效。未记录到严重副作用。肉毒杆菌毒素是许多神经系统疾病的一种有用的对症治疗方法，也是神经学新亚专业“介入神经学”中主要的治疗方式之一。
