[基础治疗是否会影响类风湿关节炎继发淀粉样变性的发展？]
[Does the basic therapy affect the development of secondary amyloidosis in rheumatoid arthritis?].
作者信息
Prokaeva T B, Alekberova Z S, Radenska-Lopovok S G, Tiitinen S, Kaarela K, Kautiainen H
出版信息
Ter Arkh. 1995;67(5):47-9.
Anti-rheumatic drug treatments were studied in 260 patients from Finland and Russia suffering from rheumatoid arthritis (RA) with or without biopsy-proven secondary amyloidosis (RSA). Chloroquine was used for longer period in RSA group in Russia (p = 0.003) and in Finland (p = 0.06). In Finland chloroquine was used more often in the RSA group (p = 0.02), and sulphasalazine (p = 0.02), D-penicillamine (p = 0.03) and cytotoxics (p = 0.04) in the control group. The role of therapy in the prevention of RSA in chronic inflammation is discussed.
对来自芬兰和俄罗斯的260例患有类风湿性关节炎（RA）且有或无活检证实的继发性淀粉样变性（RSA）的患者进行了抗风湿药物治疗研究。在俄罗斯的RSA组（p = 0.003）和芬兰（p = 0.06），氯喹的使用时间更长。在芬兰，RSA组更常使用氯喹（p = 0.02），而对照组更常使用柳氮磺胺吡啶（p = 0.02）、青霉胺（p = 0.03）和细胞毒性药物（p = 0.04）。讨论了治疗在预防慢性炎症中RSA的作用。
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