Mukhin N A, Serov V V, Kornev B M, Kogan E A, Drozdova A S, Shukurova R A, Semenkova E N, Lopatkina T N, Ovchinnikov A A
Ter Arkh. 1995;67(5):68-71.
Upon analysis of 550 cases of different chronic diffuse pulmonary diseases included in a group of interstitial diseases of the lungs (IDL) the authors came to the conclusion that IDL incorporate such variants as alveolitis, pulmonary vasculitis and pulmonary hemorrhages; granulomatosis covers exogenic allergic alveolitis, alveolitis in chronic active hepatitis; vasculitis group includes such rare diseases as necrotizing sarcoid granulomatosis vasculitis and lymphoid granulomatosis; fibrosing alveolitis--secondary alveolitis in sclerodermia systematica, rheumatoid arthritis, Sjogren's disease, chronic active hepatitis. Knowledge of IDL etiology (environmental, occupational, induced by radionuclides, drugs, viruses, fungi) with focus on drug affection of the lungs is thought of value. Biopsy and bronchial lavage findings are compared clinically and morphologically. Mechanisms of pulmonary fibrosis and approaches to inhibition of pulmonary fibrosis progression are outlined.
在对一组肺间质疾病（IDL）中包含的550例不同慢性弥漫性肺部疾病进行分析后，作者得出结论，IDL包括肺泡炎、肺血管炎和肺出血等类型；肉芽肿病涵盖外源性过敏性肺泡炎、慢性活动性肝炎中的肺泡炎；血管炎组包括坏死性结节病肉芽肿性血管炎和淋巴样肉芽肿病等罕见疾病；纤维化肺泡炎——系统性硬皮病、类风湿性关节炎、干燥综合征、慢性活动性肝炎中的继发性肺泡炎。了解IDL的病因（环境、职业、放射性核素、药物、病毒、真菌所致），尤其是关注药物对肺的影响具有重要意义。对活检和支气管灌洗结果进行了临床和形态学比较。概述了肺纤维化的机制以及抑制肺纤维化进展的方法。
