Ljunggren B, Möller H
Acta Derm Venereol. 1978;58(2):125-30.
A series of agents with alleged photosensitizing properties has been studied in mice by a quantitative in vivo method for acute drug phototoxicity. The method, originally developed for phenothiazine studies, was found suitable for several drug groups with varying mechanism of action, such as tetracyclines, protoporphyrin and psoralens. In the sulfa group only sulfanilamide was active, although weakly. Phototoxicity in vivo, hitherto not demonstrated, was observed with griseofulvin, nalidixic acid, imperatorin, kynurenic acid and amiodarone.
通过一种定量体内急性药物光毒性方法，对一系列据称具有光敏特性的药物进行了小鼠实验研究。该方法最初是为吩噻嗪研究而开发的，发现适用于几种作用机制不同的药物组，如四环素、原卟啉和补骨脂素。在磺胺类药物组中，只有磺胺具有活性，尽管活性较弱。灰黄霉素、萘啶酸、欧前胡素、犬尿氨酸和胺碘酮在体内均观察到了迄今尚未证实的光毒性。
