Piercy K T, Myers R D
Department of Pharmacology, School of Medicine, East Carolina University, Greenville, NC 27858, USA.
Alcohol. 1995 May-Jun;12(3):207-11. doi: 10.1016/0741-8329(94)00084-q.
The present experiments were designed to determine: 1) the pattern of preference for different concentrations of ethanol in the female Syrian golden hamster (Mesocricetus auratus), and 2) the influence of drinking ethanol on their intakes of food and total calories. A standard three-bottle preference test was undertaken in six female hamsters over an 11-day period in which water was offered together with ethanol, which was increased in concentration over 11 days from 3% to 50% as follows: 3%, 5%, 7%, 9%, 12%, 15%, 20%, 25%, 30%, 40%, 50%. Then, each hamster was offered its individually preferred concentration for a period of 8 days until the intake of ethanol had stabilized. During the preference testing for 3-25% solutions, the proportional intakes ranged between 0.6 and 0.8 whereas the mean absolute amount consumed per day increased from 2.3 to 16.1 g/kg at the 25% concentration. However, at the 50% concentration, ethanol drinking declined substantially to 8.7 g/kg per day. The overall mean percent concentration of ethanol preferred by the hamsters was 24.2 +/- 1.5%. During the following 8-day period when the maximally preferred concentration of ethanol of each hamster was offered with water, the mean intake of ethanol was 17.9 +/- 1.1 g/kg per day. Throughout the test sequence, the caloric intake of the animals was maintained in that calories obtained from food declined at the same rate as the calories obtained from ethanol in rising concentrations.(ABSTRACT TRUNCATED AT 250 WORDS)
1）雌性叙利亚金仓鼠（Mesocricetus auratus）对不同浓度乙醇的偏好模式；2）饮用乙醇对其食物摄入量和总热量摄入的影响。对六只雌性仓鼠进行了为期11天的标准三瓶偏好测试，测试中提供水和乙醇，乙醇浓度在11天内从3%增加到50%，具体如下：3%、5%、7%、9%、12%、15%、20%、25%、30%、40%、50%。然后，给每只仓鼠提供其各自偏好的浓度，持续8天，直至乙醇摄入量稳定。在对3%-25%溶液的偏好测试中，比例摄入量在0.6至0.8之间，而在25%浓度下，每天消耗的平均绝对量从2.3克/千克增加到16.1克/千克。然而，在50%浓度时，乙醇饮用量大幅下降至每天8.7克/千克。仓鼠偏好的乙醇总体平均浓度百分比为24.2±1.5%。在接下来的8天里，给每只仓鼠提供其最大偏好浓度的乙醇并搭配水，乙醇的平均摄入量为每天17.9±1.1克/千克。在整个测试过程中，动物的热量摄入保持稳定，即随着乙醇浓度升高，从食物中获取的热量下降速度与从乙醇中获取的热量下降速度相同。（摘要截选至250字）
